Overview
Bio2Byte investigates how protein dynamics, conformational states, and experimental data relate to amino acid sequences. The group uses data integration, analysis, and machine learning to unravel physical and chemical principles and connect them to biological events. They provide online sequence-based biophysical predictions and have migrated their infrastructure to the Tier-1 Cloud provided by the Flemish Supercomputer Center (VSC).
In the news
- The review by Tamás Lázár 𝗳𝗿𝗼𝗺 𝗼𝘂𝗿 𝗴𝗿𝗼𝘂𝗽, together with collaborators, covers the current state of 𝗯𝗶𝗼𝗺𝗼𝗹𝗲𝗰𝘂𝗹𝗮𝗿 𝗰𝗼𝗻𝗱𝗲𝗻𝘀𝗮𝘁𝗲𝘀 𝗮𝗻𝗱 𝗔𝗜-𝗱𝗿𝗶𝘃𝗲𝗻 𝗺𝗼𝗱𝗲𝗹𝗹𝗶𝗻𝗴 𝗼𝗳 𝗶𝗻𝘁𝗿𝗶𝗻𝘀𝗶𝗰𝗮𝗹𝗹𝘆 𝗱𝗶𝘀𝗼𝗿𝗱𝗲𝗿𝗲𝗱 𝗽𝗿𝗼𝘁𝗲𝗶𝗻𝘀 (𝗜𝗗𝗣𝘀), the link between 𝗰𝗼𝗻𝗱𝗲𝗻𝘀𝗮𝘁𝗲 𝗮𝗴𝗶𝗻𝗴 𝗮𝗻𝗱 𝗱𝗶𝘀𝗲𝗮𝘀𝗲, and emerging directions in 𝗯𝗶𝗼-𝗶𝗻𝘀𝗽𝗶𝗿𝗲𝗱 𝗺𝗮𝘁𝗲𝗿𝗶𝗮𝗹𝘀. A great snapshot of how far the disorder/phase-separation field has come — and where it's heading next,
- It was very nice having you Marina Navarro! Wishing you all the best in your PhD! 🌟
- 𝗣𝗿𝗲𝗽𝗿𝗶𝗻𝘁 𝗮𝗹𝗲𝗿𝘁!! 𝗔𝗻𝗼𝘁𝗵𝗲𝗿 𝘀𝘂𝗰𝗰𝗲𝘀𝘀𝗳𝘂𝗹 𝗰𝗼𝗹𝗹𝗮𝗯𝗼𝗿𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗖𝗼𝗺𝗽𝗢𝗺𝗶𝗰𝘀 𝗮𝗻𝗱 𝗩𝗜𝗕 𝗗𝗮𝘁𝗮 𝗖𝗼𝗿𝗲: 𝗦𝗰𝗼𝗽𝟯𝗣-𝗧𝗼𝗼𝗹𝗸𝗶𝘁 𝗦𝗰𝗼𝗽𝟯𝗣-𝗧𝗼𝗼𝗹𝗸𝗶𝘁 enables researchers to 𝗲𝘅𝗽𝗹𝗼𝗿𝗲 𝗣𝗧𝗠𝘀, 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀, 𝗽𝗲𝗽𝘁𝗶𝗱𝗲𝘀 𝗶𝗻 𝘁𝗵𝗲𝗶𝗿 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗰𝗼𝗻𝘁𝗲𝘅𝘁 by integrating protein annotations, structural mapping, residue interaction networks, and biophysical profiling. 𝗧𝗿𝘆 𝘁𝗵𝗲 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝘃𝗲 𝗶𝗻𝘁𝗲𝗿𝗳𝗮𝗰𝗲 𝗮𝗻𝗱 𝗹𝗲𝘁 𝘂𝘀
- 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗨𝗽𝗱𝗮𝘁𝗲𝘀 𝗮𝘁 𝗕𝗶𝗼𝟮𝗕𝘆𝘁𝗲 Charlotte Crauwels, PhD student in our group, completed a research stay at the group of Timothy Jenkins at DTU. During her research stay, she designed more than 30,000 binders targeting GPCRs. Thanks to Charlotte and Timothy for strengthening the collaboration between the two research groups!
- It was very nice having you Paula Florencia Nuñez! Best of luck with your PhD! 😊
- 𝗪𝗲 𝗮𝗿𝗲 𝗵𝗮𝗽𝗽𝘆 𝘁𝗼 𝘄𝗲𝗹𝗰𝗼𝗺𝗲 Sude Gunes 𝗮𝘀 𝗮 𝗷𝗼𝗶𝗻𝘁 𝗣𝗵𝗗 𝘀𝘁𝘂𝗱𝗲𝗻𝘁! 𝗔𝗯𝗼𝘂𝘁 𝗦𝘂𝗱𝗲: Sude Gunes joined the lab in March 2026 as a joint PhD student affiliated with both UGent (CompOmics, VIB-UGent Center for Medical Biotechnology) and VUB (Bio2Byte). She holds a Bachelor’s degree in Bioengineering and Master's degree in Polymer Science and Engineering from Izmir Institute of Technology in Turkiye. 𝗦𝘂𝗱𝗲’𝘀 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗮𝘁 𝗕𝟮𝗕 𝗮𝗻𝗱 𝗖𝗼𝗺𝗽𝗢𝗺𝗶𝗰𝘀: Sude's work focuses on
- We were excited to showcase the 𝗦𝗰𝗼𝗽𝟯𝗣 𝗧𝗼𝗼𝗹𝗸𝗶𝘁 at #𝗚𝗖𝗖𝟮𝟬𝟮𝟲 in Clermont-Ferrand, France! Earlier this month, our colleagues Adrián Díaz (Bio2Byte), Pathmanaban Ramasamy (Bio2Byte & CompOmics), and Natalia Tichshenko (CompOmics) attended the Galaxy Community Conference, where we showcased the latest evolution of the Scop3P Toolkit. What started as a collection of interactive Jupyter notebooks, then evolved into Voilà web applications, has now become a fully supported 𝗚𝗮𝗹𝗮𝘅𝘆 𝗜𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝘃𝗲
- Congratulations Konstantina Tzavella ! 👏👏
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