LinkedInยทWednesday, 26 August 2026ยท3h ago
๐๐๐ ๐๐ฎ๐ฟ๐ด๐ฒ๐ ๐ฑ๐ถ๐๐ฐ๐ผ๐๐ฒ๐ฟ๐ ๐ต๐ฎ๐ ๐ฎ๐ป ๐ฎ๐ป๐๐ถ๐ด๐ฒ๐ป ๐ฝ๐ฟ๐ผ๐ฏ๐น๐ฒ๐บ โ ๐ฎ๐ป๐ฑ ๐ถ๐'๐ ๐ป๐ผ๐ ๐ฎ๐ฏ๐ผ๐๐ ๐๐ฒ๐ป๐๐ถ๐๐ถ๐๐ถ๐๐.โฆ
Aspect Analytics
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๐๐๐ ๐๐ฎ๐ฟ๐ด๐ฒ๐ ๐ฑ๐ถ๐๐ฐ๐ผ๐๐ฒ๐ฟ๐ ๐ต๐ฎ๐ ๐ฎ๐ป ๐ฎ๐ป๐๐ถ๐ด๐ฒ๐ป ๐ฝ๐ฟ๐ผ๐ฏ๐น๐ฒ๐บ โ ๐ฎ๐ป๐ฑ ๐ถ๐'๐ ๐ป๐ผ๐ ๐ฎ๐ฏ๐ผ๐๐ ๐๐ฒ๐ป๐๐ถ๐๐ถ๐๐ถ๐๐. ๐๐'๐ ๐ฎ๐ฏ๐ผ๐๐ ๐น๐ผ๐ฐ๐ฎ๐๐ถ๐ผ๐ป.
A recent Cell Press Blue perspective makes a compelling case: target discovery and patient stratification still lean on bulk RNA-seq and IHC H-scores,ย but these tools will never capture the heterogeneity of antigen expression and architecture of the tumor microenvironment. This missing information is crucial to determining therapeutic response.
ADC pharmacology operates across different spatial scales simultaneously and is heavily affected by tumor microenvironment structure. The authors propose a spatial multi-omics approach to spatially characterize the molecular complexity of tissue:ย
โก๏ธHigh-plex spatial proteomics for target expression
โก๏ธSpatial transcriptomics for unbiased screening for protein-encoding transcripts enriched in tumor versus adjacent normal tissue,
โก๏ธMass spectrometry imaging to detect small-molecule drugs, and intact ADC payloads and understand metabolic conditions that affect ADC processing and activity .
๐ช๐ฒ๐ฎ๐๐ฒ ๐ถ๐ ๐๐ต๐ฒ ๐ผ๐ป๐น๐ ๐๐ผ๐ณ๐๐๐ฎ๐ฟ๐ฒ ๐ฝ๐น๐ฎ๐๐ณ๐ผ๐ฟ๐บ ๐๐ต๐ฎ๐ ๐ป๐ฎ๐๐ถ๐๐ฒ๐น๐ ๐ฐ๐ผ๐บ๐ฏ๐ถ๐ป๐ฒ๐ ๐ ๐ฆ๐ ๐ฑ๐ฎ๐๐ฎ ๐๐ถ๐๐ต ๐ผ๐๐ต๐ฒ๐ฟ ๐๐ฝ๐ฎ๐๐ถ๐ฎ๐น ๐ฏ๐ถ๐ผ๐น๐ผ๐ด๐ ๐ฎ๐๐๐ฎ๐ ๐๐๐ฝ๐ฒ๐ ๐ถ๐ป ๐ฎ ๐๐ถ๐ป๐ด๐น๐ฒ ๐ถ๐ป๐๐ฒ๐ด๐ฟ๐ฎ๐๐ฒ๐ฑ ๐ฎ๐ป๐ฎ๐น๐๐๐ถ๐ ๐ฒ๐ป๐๐ถ๐ฟ๐ผ๐ป๐บ๐ฒ๐ป๐. Teams can co-register and jointly analyze antigen expression, immune contexture, and payload distribution in one workflow โ the multimodal integration this paper identifies as the field's highest-priority computational need.
If your ADC discovery or translational team is wrestling with exactly this problem, let's talk.
Congratulations to all the authors! Akila Wijerathna Yapa, James R. Mansfield, Angela Vasaturo, poh sheng JOE YEONG, and Arutha Kulasinghe. Link to paper in the comments
#spatialbiology #tissueatlas #spatiallipidomics #massspecimaging, #histologyย #neuroscience #lipidomics #bioinformatics
#Weave #ai4smox
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